Collagen Replacement Therapy® using Zyderm® and Zyplast® collagen impants, replenishes the skin's collagen layer, smoothing lines and wrinkles, and adding definition to lip borders from the inside out. And now for the first time ever, you can replace collagen through innovative new treatments made from human collagen. They're called CosmoDerm™ and CosmoPlast™. Dermal fillers ( Restylane® , Radiesse™ , Juvederm, and Artefill ) are used to restore volume and fullness to the skin to correct facial wrinkles & lines across the forehead, frownlines, around the eyes, mouth, nasolabial folds and to create fuller lips.